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Utilization of cimetidine with oral metronidazole may lengthen the 50 percent-existence and reduce plasma clearance of metronidazole.

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On the other hand, It's not clear irrespective of whether interaction with DNA by yourself is an important ingredient inside the bactericidal motion of metronidazole on anaerobic organisms.

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In sufferers stabilized on jnetoto somewhat high doses of lithium, short-phrase oral metronidazole therapy continues to be connected to elevation of serum lithium degrees and, in several instances, signs of lithium toxicity.

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Psychotic reactions are documented in alcoholic patients who ended up employing oral metronidazole and disulfiram concurrently. Metronidazole vaginal gel should not be administered to sufferers that have taken disulfiram within the very last two months.